The overall objective of the work conducted in this laboratory is to develop strategies for spatio-temporally controlled delivery of biomolecules based on an understanding of (patho)physiology. Applications include promoting bone formation around orthopedic and dental implants, healing of bone defects, augmentation of alveolar bone, and regeneration of growth plate.
This lab is equipped to: prepare biomaterial samples; immobilize biomolecules on biomaterial surfaces; form protein- and drug-loaded biodegradable microspheres; fabricate controlled release devices and tissue engineering scaffolds; isolate, culture, and characterize various types of mesenchymal cells; conduct in vitro experiments of cell-biomaterial interactions; carry out in vivo experiments to determine tissue responses; and perform quantitative colorimetric and fluorometric biochemical assays.
Additional information can be found on the other pages of this Web site.
Note that the Puleo Lab is not accepting students at this time.